762 Morphologic features and assessment of carcinomas risk development in patients with colorectal adenomas

The clinical significance of colorectal polyps emerges from the adenomacarcinoma sequence theory. This theory includes size-dependent risk of malignancy in adenomas and a failure to find minute, “de novo” carcinomas surrounded only by normal mucosa. The retrospective study was carried out on 141 colorectal adenomas diagnosed in 94 patients; male to female ratio 2.35:1. Polyps were obtained by endoscopic polypectomy performed during the total colonoscopy. Most adenomas were located in the sigmoid colon and the rectum, and the percentage decreased proximally to the right colon. Histological examination revealed that, among 141 adenomatous polyps, there were 122 (86.52%) tubular, 12 (8.51%) tubulovillous and 7 (4.96%) villous adenomas. The epithelial dysplasia was graded as mild in 57 (40.42%) adenomas, moderate in 44 (31.20%) and severe in 6 (4.25%). Invasive carcinoma was observed in 11 (7.80%), while 23 (16.31%) adenomas were without dysplasia. The percentage of severe dysplasia was greater in villous than in tubular adenomas ( P P