A Phase 2 Study of Intermittent High-Dose Cyclophosphamide Therapy of Advanced Gastrointestinal Cancer1

SUMMARY Thirty-two patients with advanced gastrointestinal carci noma were treated with intermittent high-dose cyclophosphamide on a schedule of 30 to 40 mg/kg by rapid i.v. injection given every 3 weeks. Nine patients overall and 8 of 17 previously treated patients showed objective tumor regression. These responses, however, were too transient to be accorded any clinical value.