[Effectiveness of spirolactone on the treatment of laryngeal edema and complications after H-uvulopalatopharyngoplasty for patients with obstructive sleep apnea].

Objective:To determine whether taking spirolactone orally after H-UPPP may relieve laryngeal edema and complications for patients with obstructive sleep apneaOSA. Method:Fifty patients with OSA to undergo H-UPPP operation were randomly divided equally to the intervention grouptaking spirolactone 20 mg orally twice a day for 7 days after H-UPPP or the control group, all patients received conventional therapy after H-UPPP including anti-infection, hemostatic treatment, fluid replacement and expectorant by fogged absorption. The pharyngeal wound, diet, sleep and speaking pronunciation of all patients in each group were evaluated every other day in 7 days postoperation. The minimum oxygen saturation of bloodSaOcircle2 during sleep at night each day and the period needed for staphyledema resolution of all patients were recorded and compared between each group. Result:Postoperatively, the intervention group had significantly slighter bleeding at wound site, better sleep and more legible speaking pronunciation than the control group after 3 days to 5 daysP<0.05. The wound dehiscence of the intervention group was significantly slighter than the control group within 7 days after operationP<0.05. During 3 days to 7days after operation, the intervention group had a significantly better diet than the control groupP<0.05. The average minimum SaOcircle2during sleep at night in the intervention group was significantly higher than that in the control group from 3 days to 5 days post operationP<0.05. Period needed for staphyledema resolution in the intervention group4.1+/-1.5 days was significantly shorter than that in the control group5.9+/-1.8 days P<0.05. Conclusion:Taking spirolactone orally after H-UPPP may relieve laryngeal edema and complications for OSA patients, and it will also shorten the period needed for staphyledema resolution.