Mutations linked to chromosome 17q, susceptibility breast cancer and ovarian gene.

The present invention generally refers to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human gene predisposing OVARIAN AND BREAST CANCER (BRCA1), some mutant alleles that cause susceptibility to cancer, in particular breast cancer and ovarian cancer. More specifically, the invention relates to Germline mutations in BRCA1 GENE AND THEIR USE IN THE DIAGNOSIS OF OVARIAN CANCER predisposition and breast cancers. The present invention further relates to Somatic Mutations in BRCA1 GENE IN OVARIAN CANCER AND HUMAN BREAST AND THEIR USE IN THE DIAGNOSIS AND PROGNOSIS OF SUCH CANCER.