Correlationship between Snail and E-cadherin and Cervical Lesions

Objective:To investigate the changes of E-cadherin and Snail in cervical cancers and their relationships and the clinical significance.Methods:The expression of E-cadherin and Snail in 115 cases of cervical tissues was detected by SP methods.Their relationship with genesis and development of tumors was analyzed.Results:With the development of chronic cervicitis to cervical intraepithelial tumor-like lesion(CIN)to cervical cancer,the positive expression of E-cadherin was decreased and the positive expression of Snail was increased,the difference between various tissues was significant(P0.05).The expression of E-cadherin was negatively related to that of Snail(P0.01).Conclusion:In tissues of chronic cervicitis and CIN and cervical cancer,the expression of E-cadherin is gradually decreased and the expression of Snail is gradually in creased,which induced tumor cells easy to fall off,then infiltrate and metastasize,Snail regulates the expression of E-cadherin.