mortality in patients with congestive heart failure treatment for heart failure are independent risk factors for morbidity and High levels of plasma brain natriuretic peptide and interleukin-6 after optimized

A system and method for detecting the occurrence of an event causing multiple hosts to be unresponsive. The system and method including, for a set of hosts providing services to one or more customers of a computing resource service provider, determining one or more subsets of hosts that are unresponsive, determining whether the one or more subsets of hosts that are unresponsive meet a set of criteria for an occurrence of an large-scale event affecting multiple hosts, based at least in part on a determination that the set of criteria is met, initiating a remediation action.