Amorphous substance for Idelalisib and preparation method thereof

2015 
The invention discloses an amorphous substance for Idelalisib and a preparation method of the amorphous substance for Idelalisib. The amorphous substance for Idelalisib provided by the invention usesCu-Kalpha radiation and has no sharp diffraction peaks in an X-ray powder diffraction spectrum expressed in degrees of 2theta. The amorphous substance for Idelalisib disclosed by the invention increases the solubility of Idelalisib, and is more conducive to improvement on the bioavailability of a pharmaceutical preparation. Compared with the existing crystalline Idelalisib, the solubility of Idelalisib is significantly increased, and the absorption of medicines by bodies are facilitated, so that the medicines can better play the role of treating clinical diseases. The amorphous substance can keep good physical stability and chemical stability under accelerated test conditions.
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