EARLY FUNCTIONAL STRAIN DIFFERENCES IN PRE-HYPERTROPHIC CARRIERS WITH MUTATIONS IN MYH7 AND MYBPC3 ASSESSED WITH CMR TISSUE TAGGING

The majority of familial hypertrophic cardiomyopathy (HCM) (70%) is caused by mutations in 2 sarcomere genes, MYH7 and MYBPC3. Prognosis of patients with a MYH7 mutation is worse compared with MYBPC3 patients, but no pathophysiological mechanism causing this outcome has yet been unravelled. We