Abstract TP455: Treatment With Trifluoromethoxyphenyl-3 (1propionylpiperidin-4-yl) Urea Improves Cognitive Functions and Endothelium Dependent Dilation in Penetrating Arterioles From Hypertensive Rats With Bilateral Common Carotid Stenosis

Soluble epoxide hydrolase (sEH) converts epoxyeicosatrienoic acids (EETs), arachidonic acid metabolites produced by cytochrome 450 enzymes, into less metabolically active compounds. sEH inhibitors have been proposed to have vascular and neural protective effects in stroke models. Studies from our lab showed that bilateral carotid artery stenosis (BCAS), a physiologically relevant model of cognitive impairment, impairs endothelium dependent dilation in penetrating arterioles (PAs) from stroke prone spontaneously hypertensive rats (SHRSPs). We hypothesized that treatment of SHRSPs with BCAS with the sEH inhibitor, trifluoromethoxyphenyl-3 (1propionylpiperidin-4-yl) urea (TPPU) would alleviate cognitive dysfunction and improve endothelium dependent dilation in PAs. Data are shown as mean ± SEM, vehicle vs TPPU, and p <0.05 (an n=3 to 12 in each group). After 8 weeks of BCAS, TPPU treated rats showed improved short-term memory (novel exploration quotient, 90 minutes retention time: 0.5 ± 0.06 vs 0.6 ± 0.04), ...