Clinical and laboratory parameters associated with death in acute pancreatitis
2017
Introduction. Acute pancreatitis is an inflammatory condition having the
significant mortality rate in the case of severe forms of disease. The aim of
this study was to investigate putative factors of increased mortality with
contradictory prior evidence, and to reveal factors that were insufficiently
explored previously. Methods. A prospective cohort study with nested
case/control design included all adult patients treated for acute
pancreatitis in Clinical Center of Kragujevac, Serbia, during the 3-year
period (from October 2011 to December 2014). The cases (n=19) were patients
who died, while the controls (n=113) were patients who survived. The
associations between putative risk factors and the study outcomes were tested
by univariate and multivariate logistic regressions, and expressed as crude
and adjusted odds ratios (OR) with corresponding 95% confidence intervals
(CI). Results. Significant association with the lethal outcome in acute
pancreatitis was found for advanced age (adjusted OR 1.12, 95%CI 1.02-1.23),
presence of significant comorbidities (adjusted OR 10.62, 95%CI 1.01-111.39),
higher interleukin-8 (IL-8) value on third day from onset of symptoms
(adjusted OR 1.05, 95%CI 1.02-1.08), use of tramadol and/or morphine
(adjusted OR 47.34, 95%CI 3.21-699.08), BISAP score ≥ 3 in the first 24 hours
(adjusted OR 48.11, 95%CI 3.14-736.29), and prophylactic use of antibiotics
(adjusted OR 0.07, 95%CI 0.01-0.85). Conclusion. Advanced age, significant
comorbidities, use of tramadol and/or morphine and more severe disease as
assessed by BISAP score can increase the risk for death in acute
pancreatitis, while prophylactic use of antibiotics may have a protective
role. [Projekat Ministarstva nauke Republike Srbije, br. 175007]
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
1
Citations
NaN
KQI