Clinical useful quantities of [18F]fluoride produced by 6 MeV proton irradiation of a H2 18O target

Abstract Routine production of [ 18 F]fluoride has been carried out by 6 MeV proton irradiation of H 2 18 O water using a small-volume silver target vessel. By optimizing the target design, a 120 min irradiation of 600 μl 97% enriched [ 18 O]H 2 O at a beam current of 10 μA gives a practical yield of 5700±80 MBq (154±2 mCi). The produced [ 18 F]fluoride has been used for no-carrier-added synthesis of 2- 18 FDG.