Plasma FPA and Bβ 15-42 levels in chronic renal failure

Fibrinopeptide A (FPA) and fibrinopeptide Bβ15-42 (Bβ15-42) levels were examined in various diseases, according to the methods of Nossel and Kudryk, respectively.The values elevated in chronic liver disease, chronic hematopoietic malignancy, cerebral thrombosis and chronic renal failure (CRF). Among those diseases remarkable elevation was observed in CRF. During dialysis treatment for CRF relulted in decrease in FPA levels, not in Bβ15-42 levels. The Bβ15-42 levels were well correlated with serum creatinine levels. Significant elevation of Bβ15-42 could be observed in CRP-positive group.From these findings, it could be concluded that Bβ15-42 was a marker detecting hyperfibrino (geno) lytic condition, but that in renal failure the values should be discussed in relation with serum creatinine values.