Natural antioxidants in the management of Parkinson’s disease: review of evidence from cell line and animal models

Abstract Parkinson’s disease (PD) is a chronic progressive neurodegenerative disease. It results from the death of dopaminergic neurons. The pathophysiological mechanisms in idiopathic PD include the production of α-synuclein and mitochondrial respiratory function-affecting complex I, caused by reactive oxygen species. Therefore, the use of natural antioxidants in PD may provide an alternative therapy that prevents oxidative stress and reduces disease progression. In this review, the effects of hydroxytyrosol, Ginkgo biloba, Withania somnifera, curcumin, green tea, and Hypericum perforatum in PD animal and cell line models are compared and discussed. The reviewed antioxidants show evidence of protecting neural cells from oxidative stress in animal and cell models of PD. However, the clinical efficacy of these phytochemicals needs to be optimised and further investigated. Please cite this article as: Abdul-Latif R, Stupans I, Allahham A, Adhikari B, Thrimawithana T. Natural antioxidants in the management of Parkinson’s disease: review of evidence from cell line and animal models. J Integr Med. 2021; Epub ahead of print.