Stereoselective access to (Z)-α,γ-diazido-α,β-unsaturated esters via Lewis acid-mediated 1,3-diazidation of α,α-dimethoxy-β,γ-unsaturated esters with trimethylsilyl azide
2015
Abstract The synthesis of α,γ-diazido-α,β-unsaturated esters is carried out via a Lewis acid-mediated 1,3-diazidation of α,α-dimethoxy-β,γ-unsaturated esters using two equivalents of trimethylsilyl azide. The reaction proceeds in a highly stereoselective manner to provide only the ( Z )-stereoisomers of the diazide products. The optimization and scope of the new method are discussed, and the utility of the products is demonstrated in the synthesis of bis-1,2,3-triazole derivatives.
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