Green synthesis and anxiolytic activity of some new dibenz-[1,4] diazepine-1-one analogues

Abstract A facile, green approach for the synthesis of some new dibenz[1,4] - diazepine-1-one by a three component reaction of Diamine, 1,3 diketone and aromatic aldehyde using oxalic acid as catalyst in water is described. The products are formed in good yields (92–94%). Newly synthesized dibenz [1,4]-diazepine-1-one analogues were evaluated for the anxiolytic activity by the elevated plus maze method. From the activity data it is observed that compounds, 4g , 4h and 4k show promising anxiolytic activity.