EXPERIMENTAL MODELS OF PRESSURE OVERLOAD: VARIABILITY AND REPRODUCIBILITY OF TRANSVERSE AORTIC CONSTRICTION IN PRODUCING LEFT VENTRICULAR HYPERTROPHY IN MICE

Murine models of pressure overload using transverse aortic constriction (TAC) have undoubtedly helped us to further our mechanistic understanding of cardiac hypertrophy. During TAC, aorta is ligated (over a curved blunt needle) between the brachiocephalic trunk and the left common carotid artery