Hemodynamic and metabolic changes following cerebral revascularization in patients with cerebral occlusive diseases.

AbstractChanges in cerebral hemodynamics and metabolism following cerebral revascularization were evaluated using positron emission tomography (PET). Ten patients who had received nonsurgical treatment for 3-6 months for minor completed stroke underwent superficial temporal artery to middle cerebral artery (STAMCA) bypass surgery. All patients showed no extensive infarction on MR, and responsible vascular lesions were detected in the anterior circulation. A PET study of cerebral blood flow (CBF)/ oxygen extraction fraction (OEF), cerebral metabolic rate for oxygen (CMR02), and cerebral metabolic rate for glucose (CMRGlu) measurements was performed before and 7.5 months after surgery using a steady state technique. Angiographically, anastomotic sites were patent in all patients. Seven patients showed neurological improvement after surgery and the others showed no improvement. The decreases in CBF, CMR02 and CMRGlu recovered to some extent not only on the lesion side but also on the contralateral side after...