Three new sesquiterpene lactones from Carpesium abrotanoides

Abstract Three new sesquiterpene lactones, 5 α -hydroxy-4 α ,15-epoxy-11 α H-eudesman-12,8 β -olide ( 1 ), carabrol-4- O -palmitate ( 2 ) and carabrol-4- O -linoleate ( 3 ), along with five known ones, were isolated from the whole plant of Carpesium abrotanoides. The structures of new compounds were determined by extensive spectroscopic analysis, and compound 1 was also elucidated by X-ray single-crystal diffraction analysis. The cytotoxic activities of these new compounds against human leukemia cells HL-60 and human breast cancer cells MCF-7 were also evaluated by MTS method.