Cytological Findings in Cerebrospinal Fluid as Criteria of Process Activity in Multiple Sclerosis

The immunocompetent cell activity in cerebrospinal fluid in MS depends on immune biological process activity. Modifications of humoral and cell permeability can arise from the ependymal and endothelial barrier surfaces. The characteristic cells of process activity in MS are the small lymphocytes, the T and B cells, which have an increased number of ribosomes and basophilia of the cytoplasm, tendency to transformation, and an increase in the nucleoli number (Fig. 1 a).