Effect oforally administered nadolol onthe intraocular pressureinnormal volunteers

SUMMARY Forty six normalvolunteers were randomly assigned in double-blind fashion to once daily orally administered nadolol 10, 20, 40, or 80 mg for five days. Significant anddose related intraocular pressure (IOP)reductions(range 20-40%) were demonstrated bothatthreehours and24hours post dosing (p<0.001, all dosages). Thereductions in IOP were dose related (p<0-05). One subject (in the 10 mg group) failed to show a significant intraocular pressure reduction.Significant reductions in blood pressure andheart rate also were recorded at all doselevels (withtheexceptionofdiastolic pressure inthe10 mg group),though considerably less in degree than IOP reductions. Twosubjects (20 mg and80 mg groups) experienced knownside effects of ,3 blockertherapynecessitatingterminationofthe drug, andfourothersexperiencedmildsideeffects but had no difficultycompleting thestudy.Theresultshavepromptedfurtherinvestigationoftheusefulnessoflowdosesoforal'nadolol as therapyin chronicsimpleglaucomapatients.