Effects of cardiopulmonary bypass perfusion temperature on perioperative renal function in adult patients undergoing cardiac surgery

Abstract Aims and objective The primary objective was to study the effects of cardiopulmonary bypass (CPB) perfusion temperature on renal function parameters (Serum creatinine, Creatinine clearance, Urine Albumin, Urine Protein and Urine Albumin Creatinine Ratio).The secondary objective was to detect renal complications of CPB. Materials and Methods It is a prospective longitudinal study of 30 adult patients (17men; 13women; mean age : 53.37 ± 16.02 yrs) who underwent valvular heart surgery (with or without coronary artery bypass grafting). Serum creatinine, Creatinine Clearance , Urine Protein, Urine Albumin and Urine Albumin Creatinine Ratio (ACR) were collected during cardiopulmonary bypass (at 28°C, 32°C and 37°C) and postoperatively (at 12 hours ,24 hours and 48 hours). Data were analysed by one-way repeated-measures ANOVA (Analysis of variance). A significant ANOVA was followed by a Bonferroni– Holm post hoc test. Observations and Results Although serum creatinine (P Conclusions CPB with moderate hypothermia for valvular heart surgeries can be performed safely in patients with adequate renal functional reserve. The glomerular permeability across the Bowman’s capsule increases after CPB as evidenced by significant proteinuria at 12 hrs and increased albuminuria at 48 hrs after surgery. There is an increased risk of transient stage I Acute Kidney Injury after cardiopulmonary bypass which recovers within 48 hours.