Low molecular weight indole fragments as IMPDH inhibitors.

Rebekah Beevers,George Martin Buckley,Natasha Davies,Joanne L. Fraser,Francis C. Galvin,Duncan Hannah,Alan Findlay Haughan,Kerry Jenkins,Stephen Robert Mack,William R. Pitt,Andrew J. Ratcliffe,Marianna Dilani Richard,Verity Margaret Sabin,Andrew Sharpe,Sophie Caroline Williams

Low molecular weight indole fragments as IMPDH inhibitors.

2006

Rebekah Beevers
George Martin Buckley
Natasha Davies
Joanne L. Fraser
Francis C. Galvin
Duncan Hannah
Alan Findlay Haughan
Kerry Jenkins
Stephen Robert Mack
William R. Pitt
Andrew J. Ratcliffe
Marianna Dilani Richard
Verity Margaret Sabin
Andrew Sharpe
Sophie Caroline Williams

The study of non-oxazole containing indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis and in vitro inhibitory values for IMPDH II are discussed.

Keywords:

Enzyme
IMP dehydrogenase
Chemical synthesis
Bicyclic molecule
Stereochemistry
Organic chemistry
Indole test
Enzyme inhibitor
Biochemistry
Chemistry
In vitro
Molecular model

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