New method for the synthesis of metal complexes based on Pt IV and substituted nicotinamides and isonicotinamides and investigation of their antimetastatic activity

Complexes of platinum tetrachloride with substituted nicotinamides and isonicotinamides were synthesized by the reactions of the corresponding amides with hexachloroplatinic acid. All these complexes are low-toxic. The strong antimetastatic activity of these complexes against Lewis lung carcinoma and B16 melanoma experimental tumors was found in an enzyme system and was then shown in experiments on animals.