Effect of intracutaneous pyonex on analgesia and sedation in critically ill patients with mechanical ventilation.

To evaluate the effect of intracutaneous pyonex on analgesia and sedation in critically ill patients who underwent mechanical ventilation. A total of 88 critically ill patients were divided into control group and intervention group. Critical-Care Pain Observation Tool (CPOT) and Richmond Agitation and Sedation Scale (RASS) were used to evaluate pain and agitation. The dosage and treatment period of sedative and analgesic drugs in the intervention group were notably lower than the control group (p<0.05). Analgesia compliance time in the intervention group was superior to control group (p<0.05). The shallow sedation compliance rate in the intervention group was significantly higher than the control group (p<0.01). There was significant difference in blood gas analysis before and after treatment between the two groups (p<0.05). After 2 h of sedation and analgesia, heart rate (HR) in the intervention group was lower than control group, but respiratory rate (RR) was higher than the control group (p<0.05). The traditional analgesia and sedation combined with intracutaneous pyonex reduced the total amount and treatment period of sedative and analgesic drugs in critically ill patients throughout the treatment process, while it also decreased the adverse reactions such as blood pressure drops and respiratory depression.