Determination of a Binding Site of Cu, Ni, Mg, and Ca Metal Ions with Angiotensin II Peptide by Electrospray Tandem Mass Spectrometry

It is evident that several reports are not consistent with each other and that no clear agreement exists regarding the biologically active structure of Ang II during the biological process. For the study of blood pressure control and metal-peptide interaction, the influences of metal cations on the biological activity of Ang II have been also investigated.