EFFECTS OF HYPERTONIC SALINE, HAES AND DYMETHYLSULPHOXYDE ON FREE OXYGEN RADICALS IN HAEMORRHAGIC SHOCK HEMORAJ‹K fiOKTA OKS‹JEN SERBEST RAD‹KALLER‹ ÜZER‹NE H‹PERTON‹K SAL‹N, HAES VE D‹MET‹LSÜLFOKS‹T'‹N ETK‹LER‹

Background: The aim of this study was to investigate the effects of antioxidant and resuscitation fluids which were used during haemorrhagic shock on tissue ischemia. Methods: Forty New Zealand type rabbits were divided into four groups as C (control), I (hypertonic saline), H (HAES) and D (Dymethylsulphdxide-DMSO). Haemorrhagic shock was induced by bleeding from carotid artery. Thirty minutes after shock, Group C was not resuscitated while Group I was resuscitated with Hypertonic saline 7.2, Group H with 10 % HAES and Group D with HAES 10 % and DMSO. Thiobarbituric acid reactive substances (TBARS) and lactate levels in blood, liver and small bowel samples were measured. Results: There were no significant differences among the groups tissue and plasma TBARS and lactate levels. Conclusion: Resuscitation fluids and addition of antioxidants to the resuscitation fluids do not have any superiorities over each other to prevent tissue ischemic insult in haemorrhagic shock.