Efficient Derivation of Human Induced Pluripotent Stem Cells with a c-Myc-Free Non-Integrating Episomal Vector

Human induced pluripotent stem cells(hi PSCs)can self-renew indefinitely and have the potential to differentiate into all cell types in the human body,thus hold great promise in regenerative medicine,drug screening and developmental biology studies.However,integrating retroviral(Takahashi et al.,2007)or lentiviral(Hockemeyer et al.,2008)gene delivery systems and the exogenous oncogene c-Myc(Takahashi et al.,