The Discrepancy in Hardness between Clinical and Histopathological Findings in Localized Scleroderma Treated with PUVA

Topical PUVA therapy was applied to a patient with localized scleroderma. Her localized scleroderma responded very well to the topical PUVA therapy, i.e., her sclerotic skin softened to normal skin texture. However, despite this dramatic clinical change the histopathological findings did not change at all and were still “hard”.