Pretreatment Techniques and Analytical methods for phenolic endocrine disrupting chemicals in food and environmental samples

Abstract Phenolic endocrine disrupting chemicals (EDCs) have aroused peoples’ attention worldwide because of their hazards to the human health as well as their wide distributions in environmental matrices (such as air, water and soil), food samples and food packaging materials. Lots of pretreatment techniques (mainly solid phase extraction (SPE)) and detection methods (mainly chromatographic techniques) have been used to concentrate and detect the phenolic EDCs in various of samples. Bisphenol A (BPA), nonylphenol (NP) and octylphenol (OP) are representative phenolic EDCs that are the most widely distributed and obtained the most attention. Therefore, we present a review of the physicochemical properties, applications, toxicities, pretreatment techniques, detection methods, and occurrence in food, food packaging, and environmental samples of these phenolic EDCs. Furthermore, we made predictions about the research directions of these phenolic EDCs in the future, mainly including the toxicity mechanism, the applied eco-friendly materials and pretreatment techniques and so on.