Efficacy of memantine for elderly patients in the mild stage of Alzheimer's and vascular dementia in Ukraine

The aim of our research was to investigate the effectiveness of memantine treatment of Ukrainian patients with Alzheimer's (AD) and vascular dementia (VaD) depending on existing ApoE genotype. Methods It was a complex examination of 60 elderly persons (72.40 ± 1.35 years) with mild stage of AD and VD. The effectiveness of response to (20 mg/day) memantine intake was studied during the first 3 months of treatment. Efficacy of short-term treatment was determined by MMSE and the numbers of positive statistically significant changes ADAS-cog subtests. Genetic ApoE polymorphism was investigated too (using the of the PCR technique). Statistical Anova analysis was done. Results After 3 months of treatment significant changes in the overall score of Adas-cog was observed in both groups with some differences in subscale profiles. For AD patients, statistically positive changes ( P P Conclusions The memantine treatment efficacy in AD and VaD patients in mild stage of dementia was not significantly associated with an existing of Apo-E genotype polymorphism.