Clinical experience with indigenous kit-based preparation of 68 Ga-DOTATOC using commercial 68 Ge/ 68 Ga generator
2018
Abstract Pharmaceutical grade DOTATOC kits compliant with all the quality control criteria were formulated and radiolabeled with 68 Ga in high yields. Comparison with module-based 68 Ga-DOTATOC established product equivalency. Clinical utility was evaluated in patients with histopathologically confirmed well-differentiated neuroendocrine tumors. Kit-based preparation of 68 Ga-DOTATOC could identify sites of primary and metastatic disease. PET/CT images of patients conformed to the established criteria for somatostatin imaging agents and clinical expectations. Results of this study emphasize the potential of kit-based 68 Ga-DOTATOC for PET imaging of neuroendocrine tumors.
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