Muteins of Interleukin-2 for expansion of Tregs

In the present human IL-2 and Fc fusion molecules of human IL-2 that preferentially expand and activate regulatory T cells and are susceptible to large scale production are provided. Also provided herein are molecules human IgG1 Fc lacking or greatly reduced effector function and high stability despite the lack of glycosylation at N297. Also, provided herein are glycosylated peptide linkers that when expressed in mammalian cells.