C-met receptor-targeted fluorescence-guided surgery in penile squamous cell carcinoma patients
2021
1219 Introduction: In penile squamous cell carcinoma (pSCC), primary surgery aims to obtain oncologically safe margins while minimising mutilation. Surgical guidance provided by receptor-specific tracers could potentially improve margin detection and reduce excision of healthy tissue. Here, we present the first results of a prospective feasibility study for real-time intraoperative visualisation of pSCC using a fluorescent c-MET receptor targeting tracer.
Methods: Tracer performance was initially assessed ex vivo, via incubation of freshly excised pSCC in a solution containing EMI-137 (N=10). The in vivo potential of c-Met targeting and intraoperative tumor visualization was assessed after intravenous administration of EMI-137 in five pSCC patients scheduled for surgical resection. Fluorescence imaging results were related to standard pathological evaluation, including immunohistochemistry.
Results: No tracer-related adverse events were encountered. EMI-137 enabled tumour visualisation in all patients. C-MET expression was seen in all patients and the highest expression levels were seen at the tumour borders. A visual correlation was observed between c-MET expression and fluorescence signal intensity.
Conclusions: Our initial findings support the feasibility of fluorescence-guided surgical resection of c-MET receptor expressing pSCC tumours, thereby paving the way for further development of this surgical guidance approach.
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