Biodegradation of d1-synephrine: A novel pathway in Nocardia sp DM1
2013
Several organisms were tested for their ability to degrde dt-synephrine. One soil pseudomonad and a Nocardia sp have been found to efficiently utilise the compound. Norardia sp degrded synephrine by two novel routes, one involving monoamine oxidase and the other involving converston to p-hydroxyphenyl-acetaldehyde by the synephrinase enzymc The p-hydroxyphenyl-acetaldehyde was converted to p-hydroxyphenylacetic acid and finally to 2.5-dihydroxyphcnylacetic ncid which underwent ring fission between C1 and C2 atoms. The monoammine oxidase converted synephrine to p-hydroxymandehcaldehyde which was finally oxidized to 3-4-dihydroxybenzoic acid through the intermediate formation of p-hydroxymandelic acid, p-hydroxybenzaldehyde and p-hydroxybenzoic acid, 3,4-Dihydroxybenzoic acid which cleaved by an ozygenase through an orthofission. The route involving synephrinase was the major degradative pathway. However, the two pathways were found to operate simultaneously.
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