Synthesis and antiviral evaluation of 4-fluoropyrazole-3-carboxamide nucleoside derivatives

Frederic Leroy,Dominique Chaves,David Dukhan,Richard Storer,Jean-Pierre Sommadossi,Anna Giulia Loi,Alessandra Cadeddu,Maura Fanti,Nadia Boscu,Fabiola Bassetti,Michel Liuzzi,Gilles Gosselin

Synthesis and antiviral evaluation of 4-fluoropyrazole-3-carboxamide nucleoside derivatives

2008

Frederic Leroy
Dominique Chaves
David Dukhan
Richard Storer
Jean-Pierre Sommadossi
Anna Giulia Loi
Alessandra Cadeddu
Maura Fanti
Nadia Boscu
Fabiola Bassetti
Michel Liuzzi
Gilles Gosselin

A series of novel 4-fluoro-1H-pyrazole-3-carboxamide nucleoside analogues were synthesized and evaluated as potential inhibitors of RNA virus replication, including hepatitis C virus (HCV).

Keywords:

Hepatitis C virus
Virology
Nucleoside
Hepacivirus
Ribavirin
RNA virus
Carboxamide
Biology
Chemistry

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