Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels

Calmodulin (CaM) is a calcium-binding protein that can directly inhibit cardiac ryanodine receptor calcium release channels (ryanodine receptor 2 [RyR2]) [(1)][1]. CaM mutations can cause an autosomal-dominant form of catecholaminergic polymorphic ventricular tachycardia (CPVT), a syndrome