Prevention or remedy for inflammatory diseases

PREVENTION FOR PRODUCT OR Inflammatory Disease. The present inventors obtained, from a library of human antibody phage one BM095 clone expressing a neutralizing antibody anti-NR 10 mice showing strong suppressive activity of proliferation in a cell proliferation assay system Ba / F3 dependent on IL-31. When this neutralizing anti-NR 10 mouse antibody was administered to NC / Nga mice, an atopic dermatitis model which is a chronic dermatitis mouse model arises as a result of repeated application of picrila chloride, an arthritis mouse model rheumatoid and one mouse model of osteoarthritis, a significant effect of symptom suppression was observed. This revealed that neutralizing anti-NR 10 antibody is indeed effective as a therapeutic agent for inflammatory diseases. Furthermore, the present inventors have successfully obtained a neutralizing anti-human NR10 antibody, providing extremely useful therapeutic agents with practical clinical applications.