Clobazam monotherapy for partial onset or generalized onset seizures (Protocol)

Summary of findings We intend to use the principles of the Grading of Recommen-dations, Assessment,DevelopmentandEvaulation (GRADE) ap-proachtoassessthequalityofthebodyofevidenceassociatedwithspecific outcomes and construct a Summary of Findings (SoF)(Schunemann 2008). The GRADE approach appraises the qual-ity of a body of evidence based on the extent to which one can beconfident thatan estimate ofeffector association reflectstheitembeingassessed. Thequality ofabody ofevidence considerswithinstudy riskof bias (methodologic quality), thedirectness of theev-idence,heterogeneityofthedata,precision ofeffectestimatesandrisk of publication bias. R E F E R E N C E S Additional references Banerjee 2008 Banerjee PN, Hauser WA. Incidence and Prevalence. In:Engel Jr J, Pedley TA editor(s). Epilepsy. A ComprehensiveTextbook . 2nd Edition. Vol. 1 , Philadelphia: LippincottWilliams & Wilkins, 2008:45–56. Bucher 1997 Bucher HC, Guyatt GH, Griffith LE, Walter SD. Theresults of direct and indirect treatment comparisons inmeta- analysis of randomised controlled trials.