Associations Between Intake of Sugar-Containing Beverages in Infancy With Liver Fat Accumulation at School Age.

Sugar-containing beverage intake is a major risk factor for obesity in both children and adults and appears to be associated with nonalcoholic fatty liver disease (NAFLD) in adults. The purpose of this study was to examine the associations between sugar-containing beverage intake in infancy and liver fat accumulation and NAFLD among school-aged children. In a population-based prospective cohort study of 1,940 infants, we assessed sugar-containing beverage intake at 1 year with a validated Food Frequency Questionnaire (FFQ). Liver fat fraction and NAFLD (liver fat fraction ≥5.0%) were assessed with magnetic resonance imaging (MRI). Higher sugar-containing beverage intake in infancy was not associated with higher liver fat accumulation at 10 years of age when assessed continuously (0.03; 95% confidence interval [CI], -0.02, 0.07, per 1 serving/day increase of sugar-containing beverage intake) or categorically (P value for trend 0.38). However, compared to infants with 2.0 servings/day had the highest odds of NAFLD at 10 years of age (odds ratio [OR], 3.02; 95% CI, 1.34, 6.83). These associations remained borderline significant after additional adjustment for sugar-containing beverage intake and body mass index (BMI) at school age (P value 0.13). Stratified analyses showed stronger associations between sugar-containing beverage intake in infancy and NAFLD at 10 years of age among children of mothers with lower educational attainment (OR, 1.48; 95% CI, 1.12, 1.97) and among children with overweight or obesity (OR, 1.47; 95% CI, 1.05, 2.07). Conclusion: Higher sugar-containing beverage intake in infancy was associated with NAFLD in school-aged children, independent of sugar-containing beverage intake and BMI at school age. Limiting the intake of sugar-containing beverages in infancy may help prevent liver steatosis at school age.