The role of systemic therapy after local treatment in breast cancer patients with first presentation of brain metastases recurrence.

e13527Background: The role of systemic treatment was assessed after local therapy for breast cancer patients who developed central nervous system (CNS) metastasesas a first and isolated recurrence. Methods: Subjects were 128 breast cancer patients with brain metastases as the first and isolated site of recurrence that were selected from 673 consecutive breast cancer patients with brain metastases treated at the same institution. Results: Median survival from brain metastases in patients with and without systemic treatment after local therapy was respectively 15 and 4 months (p = 70 and those < 70, survival was respectively 16 and 5.5 months (p< 0.001). The median survival from brain metastasis in patients with solitary brain metastasis, with and without systemic treatment after local therapy, was respectively 22 and 7 months (p= 0.003). In the triple-negative subtype group, median survival following the diagnosis of brain metastases in those trea...