Microwave mediated syntheses of β-enamino thioic acid derivatives

Reaction of di(benzotriazole-1-yl)methanethione 1 with imines 2a–f gave air and moisture stable benzotriazolyl β-enaminothiones 3a–f. The thioacylbenzotriazoles 3a–f enable simple and efficient preparation of β-enamino thioic acid derivatives (thioamides, thioesters and dithioesters) in 74–99% yields via microwave mediated nucleophilic substitution of the benzotriazolyl moiety. C-Thioacylation with 1-thioacyl-6-nitrobenzotriazoles 7a–c is also discussed.