Синтез и способность ингибировать интегразу ВИЧ-1 2-(7-(фторбензилокси)-4-оксо-4 H -хромен-3-ил)-1- гидроксиимидазолов

A series of six new derivatives of 2-(7-(fluorobenzyloxy)-4-oxo-4 H -chromen-3-yl)-1-hydroxyimidazole have been synthesized and characterized. Prototropic tautomerism of these 1-hydroxyimidazoles is discussed. Their ability of inhibiting the catalytic activity of HIV-1 integrase in 3’-processing and strand transfer reactions has been studied. It has been found that compounds under consideration do not exhibit appreciable inhibitory activity.