A unique case of bullous drug eruption related to vancomycin and cefoperazone

We report a 52-year-old Chinese male who developed extensive erythema and tense bullae with coalesced erosion 3 days after cefoperazone administration for upper respiratory infection (figure 1A). The lesion covered 70% of his body surface with oral and genital mucosa spared. A skin biopsy showed sub-epidermal clefting with mild lymphocyte and neutrophil infiltration in the superficial dermis. Systemic workup was not significant. A bullous drug reaction to cefoperazone was suspected. He was treated [...]