Chiral Schiff Bases as Highly Active and Enantioselective Catalysts in Catalytic Addition of Dialkylzinc to Aldehydes.
2008
We have developed chiral Schiff base catalysts based on the ONO-tridentate ligand for the catalytic enantioselective addition of dialkylzinc to aldehydes. Various aldehydes were smoothly converted into corresponding optically active secondary alcohols with high enantioselectivity (up to 98 % ee) in high yield. Furthermore, we have succeeded in decreasing the catalyst loading minimum to 0.1 mol % in the chiral Schiff base-catalyzed enantioselective alkylation of aldehydes.
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