Histopathological and Immunohistochemical Analysis of Lymphoma: Study from a Tertiary Care Centre

Background - Lymphomas are malignant lymphoproliferative diseases, broadly classified by WHO into Hodgkin Lymphoma (HL) & Non-Hodgkin Lymphoma (NHL). HL should be segregated from NHL group, as clinically and histopathologically both are distinct entities, the prognosis & treatment of which varies. Material and methods- A retrospective  study was conducted in S.C.B Medical College, Cuttack, a tertiary care centre in Odisha to correlate histomorphological & immune -histochemical findings and subsequent subtyping of lymphoma according  to WHO classification. 92 cases of lymphoma were diagnosed between January 2014 to February 2017 for a period of  3 years and correlation  was done with respect to age, sex, histomorphological  and  immunohistochemical findings. Result- Out of  92 cases of lymphoma, 13 were HL (14.2%), 79 cases were NHL (85.8%). Among all NHL cases extra-nodal lymphoma constituted 28(35.4%). In NHL Male to Female ratio was 1.8:1 and maximum number of cases presented between 4th to 5th decades. Diffuse large B cell lymphoma was the most common type of NHL and Nodular sclerosis was the commonest type of HL. Conclusion- Conventional H&E stain in adjunct with immunohistochemistry was useful modality in diagnosis and classification of lymphomas.