Comparison between perfusion computed tomography and dynamic contrast-enhanced magnetic resonance imaging in assessing glioblastoma microvasculature

Abstract Purpose Perfusion computed tomography (PCT) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provide independent measurements of biomarkers related to tumor perfusion. The aim of this study was to compare the two techniques in assessing glioblastoma microvasculature. Materials and methods Twenty-five patients diagnosed with glioblastoma (14 males and 11 females; 51 ± 11 years old, ranging from 33 to 70 years) were includede in this prospective study. All patients underwent both PCT and DCE-MRI. Imaging was performed on a 256-slice CT scanner and a 3-T MRI system. PCT yielded permeability surface-area product ( PS ) using deconvolution physiological models; meanwhile, DCE-MRI determined volume transfer constant ( K trans ) using the Tofts-Kermode compartment model. All cases were submitted to surgical intervention, and CD105-microvascular density (CD105-MVD) was measured in each glioblastoma specimen. Then, Spearman’s correlation coefficients and Bland-Altman plots were obtained for PS , K trans and CD105-MVD. P Results Tumor PS and K trans values were correlated with CD105-MVD (r = 0.644, P P PS was correlated with K trans in glioblastoma (r = 0.931, P PS and K trans ( P  = 0.063). Conclusion PCT and DCE-MRI measurements of glioblastoma perfusion biomarkers have similar results, suggesting that both techniques may have comparable utility. Therefore, PCT may serve as an alternative modality to DCE-MRI for the in vivo evaluation of glioblastoma microvasculature.