Plasmid DNA Vaccines: Tissue Distribution and Effects of DNA Sequence, Adjuvants and Delivery Method on Integration into Host DNA

Sujata Manam,Brian J. Ledwith,Amy B. Barnum,Philip J. Troilo,Cindy J. Pauley,Laural B. Harper,Thomas G. Griffiths,Zhutian Niu,Lyudmila Denisova,Thy T. Follmer,Stephen Pacchione,Zhibin Wang,Carolann M. Beare,Walter J. Bagdon,Warren W. Nichols

Plasmid DNA Vaccines: Tissue Distribution and Effects of DNA Sequence, Adjuvants and Delivery Method on Integration into Host DNA

2000

Sujata Manam
Brian J. Ledwith
Amy B. Barnum
Philip J. Troilo
Cindy J. Pauley
Laural B. Harper
Thomas G. Griffiths
Zhutian Niu
Lyudmila Denisova
Thy T. Follmer
Stephen Pacchione
Zhibin Wang
Carolann M. Beare
Walter J. Bagdon
Warren W. Nichols

A variety of factors could affect the frequency of integration of plasmid DNA vaccines into host cellular DNA, including DNA sequences within the plasmid, the expressed gene product (antigen), the for

Keywords:

Plasmid
Molecular biology
DNA vaccination
DNA
Extrachromosomal DNA
Virology
Genomic library
In vitro recombination
Techniques of genetic engineering
Molecular cloning
Genetics
Biology

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