Principles and Methods for the Preparation of Drug Protein Conjugates for Immunological Studies

A brief review has been presented of the many procedures applicable for the preparation of hapten-protein conjugates that can be used to elicit antibodies to biologically interesting compounds. This review has been organized in a way to make it easier for the working scientist to recognize and thus utilize methods that would be suitable for his own research problems. Despite the recent upsurge in the application of immunological methods for the investigation of small biological molecules, there are still many more applications possible, and it is hoped that this review will encourage and facilitate some of them.