Urokinase-type plasminogen activator receptor as a predictor of poor outcome in patients with systemic inflammatory response syndrome.

RESULTS: The plasma level of uPA was lower in the SIRS group than in the non-SIRS group and controls ( P 0.05). The plasma level of uPAR increased in the SIRS group compared with the non-SIRS group and controls ( P<0.001 and P<0.001). There was a signifi cant elevation of uPAR in sepsis patients, MODS patients and non-survivors as compared with non-sepsis patients, non-MODS patients and survivors respectively (all P<0.05). Plasma uPAR levels were positively correlated with APACHE II score ( r=0.575, P<0.001) and SOFA score (r=0.349, P=0.013). AUCs for the prediction of SIRS mortality were 0.67 and 0.51, respectively, for uPA and uPAR.