Clinical research of the effect of statin on non-ischemic heart failure

Objective:To investigate the efficacy of statin on non-ischemic heart failure patients.Methods:A total of 60 non-ischemic heart failure patients after standard therapy for 1 month were randomly divided into atorvastatin group(n=28) and control group(n=32).The changes on the degree of New York heart association(NYHA),brain natriuretic Peptide(BNP),left ventricular ejection fraction(LVEF),left ventricular end-diastolic dimension(LVEDD) and six-minutes walk distance(6MWD) were observed after 12 weeks and 24 weeks.Results:In atorvastatin group,NYHA stage,BNP and 6MWD significantly improved(P0.05 all),and more than those of control group(P0.05) after 12 weeks treatments,LVEDD significantly reduced and LVEF significantly increased(P0.05 all) and improved more than those of control group(P0.05) after 24 weeks treatments.Conclusion:Statin can improve heart function,BNP and 6MWD in chronic non-ischemic heart failure patients after short-term treatments and may increase LVEF and reduce LVEDD after mid-term or long-term treatments.Statin is helpful for chronic heart failure patients.